Recently, a triple mutant variant of the COVID-19 virus has been identified in India. Let’s delve into what experts have to say about this new development.
Amidst the surge in COVID-19 cases across the country, a new variant of the virus has emerged in the state of West Bengal. Termed the ‘triple mutant variant’ or the ‘Bengal strain’ of COVID-19, it is reported to be more contagious compared to other strains. This variant is rapidly spreading in West Bengal and has also been detected in samples from Delhi and Maharashtra. Although there is currently insufficient evidence regarding its impact on vaccine efficacy, the presence of the E484K mutation raises concerns. E484K is a significant immune evasion variant found in various parts of the world, which can potentially reduce vaccine effectiveness by bypassing the immune system.
As the name suggests, a ‘triple mutant variant’ arises when three mutations of a virus converge to form a new variant. In this case, the three mutations involve a deletion and two alterations in the spike protein—specifically, the deletion of H146 and Y145, and mutations in E484K and D614G. This ‘triple mutant variant’, designated as ‘B.1.618’, is primarily spreading in West Bengal and is the second lineage of the SARS-CoV-2 virus identified in India. Previously, a ‘double mutant variant’ known as ‘B.1.617’ was detected in India, with the most recent observation on March 17. While this variant’s lineage is predominantly found in India, its members have been detected in other countries such as the US, Singapore, Switzerland, and Finland.
Here are five key points provided by Dr. Rajesh Kumar Pande regarding the triple mutant variant of COVID-19:
- The triple mutant variant is highly contagious and spreading rapidly, even more so than the initial surge of the virus. Regardless of vaccination status, it is advised to maintain social distancing and limit outings.
- While there is uncertainty regarding the impact of this variant on vaccine efficacy, immunization appears to reduce the severity of COVID-19 symptoms.
- The triple mutant variant originated from the combination of three different COVID-19 strains, evolving from a previous double mutation.
- Current evidence suggests that none of the significant virus variants are associated with increased severity, but the UK variant has demonstrated higher transmissibility.
- It is recommended to venture outside only in emergencies and to adhere strictly to precautionary measures, as the mutations of the virus are becoming stronger amidst the surge in COVID-19 cases.
Experts express concerns that the triple mutant variant may affect vaccine efficacy due to its major mutation, E484K, which enables it to evade the immune system. This mutation has also been observed in the Brazilian and South African variants of the virus. Taking necessary precautions remains vital to stay safe amidst these developments.